United, make three changes following their FA Cup replay win over Wolves in the week: Romero, Mata and Greenwood all make way with De Gea, Shaw and Pereira coming in.
Liverpool are unchanged from the side that defeated Tottenham 1-0 in London, however Fabinho and Matip both return to the bench after injury layoffs.
SUBS: Diogo Dalot, Eric Bailly, Mason Greenwood, Jesse Lingard, Sergio Romero, Juan Mata, Phil Jones.
MANCHESTER UNITED (4-2-3-1): David de Gea; Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire, Luke Shaw; Fred, Nemanja Matic; Daniel James, Andreas Pereira, Brandon Williams; Anthony Martial.
SUBS: Takumi Minamino, Curtis Jones, Adam Lallana, Divock Origi, Adrian, Fabinho, Joel Matip.
LIVERPOOL (4-3-3): Alisson; Trent Alexander-Arnold, Joe Gomez, Virgil van Dijk, Andy Robertson; Alex Oxlade-Chamberlain, Jordan Henderson, Georginino Wijnaldum; Mohamed Salah, Roberto Firmino, Sadio Mane.